Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak

被引：28

作者：

Amaral, Sandra ^{[1
]}

Mota, Paula ^{[1
]}

Rodrigues, Ana Sofia ^{[1
]}

Martins, Luis ^{[1
]}

Oliveira, Paulo J. ^{[1
]}

Ramalho-Santos, Joao ^{[1
]}

机构：

[1] Univ Coimbra, Fac Sci & Technol, Dept Zool, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal

来源：

FEBS LETTERS | 2008年 / 582卷 / 30期

关键词：

Aging; Male reproductive tract; Testis; Stress;

D O I：

10.1016/j.febslet.2008.11.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

To address the possibility that mitochondria are involved in the age-related loss of testicular function, we characterized mitochondrial bioenergetics in rat testis. A peak of mitochondrial functionality was detected in adult animals, with a decrease in both young and older animals. In the latter group a decrease in mitochondrial function was matched with an increase in proton leak and expression and activity of uncoupling protein 2 (UCP2), suggesting that proton leak may be involved in managing age-dependent mitochondrial dysfunction. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：4191 / 4196

页数：6

共 36 条

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