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Mitochondria, oxidants, and aging

被引：4411
作者：
Balaban, RS
Nemoto, S
Finkel, T
机构：
[1] NIH, Cardiovasc Branch, Bethesda, MD 20892 USA
[2] NIH, Cardiac Energet Lab, Bethesda, MD 20892 USA
来源：
CELL | 2005年 / 120卷 / 04期
关键词：
D O I：
10.1016/j.cell.2005.02.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要：
The free radical theory of aging postulates that the production of intracellular reactive oxygen species Is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.
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收藏
页码：483 / 495
页数：13
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