Asymmetric inheritance of oxidatively damaged proteins during cytokinesis

被引：492

作者：

Aguilaniu, H

Gustafsson, L

Rigoulet, M

Nyström, T ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Cell & Mol Biol Microbiol, Gothenburg, Sweden

[2] Chalmers Univ Technol, Dept Mol Biotechnol, S-41296 Gothenburg, Sweden

[3] Univ Victor Segalen, CNRS, Inst Biochim & Genet Cellulaires, Bordeaux, France

来源：

SCIENCE | 2003年 / 299卷 / 5613期

关键词：

D O I：

10.1126/science.1080418

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Carbonylated proteins were visualized in single cells of the budding yeast Saccharomyces cerevisiae, revealing that they accumulate with replicative age. Furthermore, carbonylated proteins were not inherited by daughter cells during cytokinesis. Mother cells of a yeast strain lacking the sir2 gene, a life-span determinant, failed to retain oxidatively damaged proteins during cytokinesis. These findings suggest that a genetically determined, Sir2p-dependent asymmetric inheritance of oxidatively damaged proteins may contribute to free-radical defense and the fitness of newborn cells.

引用

页码：1751 / 1753

页数：3

共 15 条

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