The Sir2 family of protein deacetylases

被引：1299

作者：

Blander, G ^{[1
]}

Guarente, L ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2004年 / 73卷

基金：

美国国家卫生研究院;

关键词：

Sir2; deacetylase; NAD(+); caloric restriction; aging;

D O I：

10.1146/annurev.biochem.73.011303.073651

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The yeast SIR protein complex has been implicated in transcription silencing and suppression of recombination. The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in organisms ranging from archaea to humans. Interestingly, Sir2 is active as an NAD(+)-dependent deacetylase, which is broadly conserved from bacteria to higher eukaryotes. In this review, we discuss the role of NAD(+), the unusual products of the deacetylation reaction, the Sir2 structure, and the Sir2 chemical inhibitors and activators that were recently identified. We summarize the current knowledge of the Sir2 homologs from different organisms, and finally we discuss the role of Sir2 in caloric restriction and aging.

引用

页码：417 / 435

页数：19

共 88 条

[1]

Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry [J].