5-HT receptor classification and nomenclature: Towards a harmonization with the human genome

被引：308

作者：

Hoyer, D ^{[1
]}

Martin, G ^{[1
]}

机构：

[1] ROCHE BIOSCI,BIOL RES CTR,PALO ALTO,CA 94304

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 4-5期

关键词：

5-HT receptors; nomenclature; classification; human genome;

D O I：

10.1016/S0028-3908(97)00036-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Molecular biology has dramatically advanced our knowledge and understanding of receptors for 5-hydroxytryptamine (5-HT). The existence of multiple 5-HT receptors defined using traditional pharmacological and biochemical approaches has now been amply confirmed, but gene products encoding putative ''new'' 5-HT receptors have also been discovered. In some cases, the absence of suitably selective agonists and antagonists has hampered determination of a physiological role for these gene products. This makes their classification as formally recognised receptors premature. (C) 1997 Elsevier Science Ltd.

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页码：419 / 428

页数：10

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