Cyclophilin a plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by spinoculation

被引:26
作者
Saphire, ACS [1 ]
Bobardt, MD [1 ]
Gallay, PA [1 ]
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
关键词
D O I
10.1128/JVI.76.9.4671-4677.2002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Cyclophilin A (CypA) is necessary for effective human immunodeficiency virus type 1 (HIV-1) replication. However, the functions of CypA and the precise steps at which CypA acts in the HIV-1 life cycle remain to be determined. By using a methodology that bypasses the need for attachment factors-spinoculation-we present evidence that CypA participates in both entry and postentry events.
引用
收藏
页码:4671 / 4677
页数:7
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