Invasive pneumococcal disease in Singapore children

被引：24

作者：

Chia-Yin, Chong ^{[1
]}

Koh-Cheng, Thoon ^{[1
]}

Yee-Hui, Mok ^{[1
]}

Nancy, Tee Wen-Sim ^{[1
]}

机构：

[1] KK Womens & Childrens Hosp, Singapore 229899, Singapore

来源：

VACCINE | 2008年 / 26卷 / 27-28期

关键词：

pneumococcal; epidemiology; serotypes;

D O I：

10.1016/j.vaccine.2008.04.035

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: Our retrospective study examined community-acquired invasive pneurnococcal disease (IPD) in children admitted to KK Women's and Children's Hospital, Singapore. Methods: All pneumococcal isolates from sterile sites from 1997 to 2004 were surveyed. Results: There were 147 positive pneumococcal isolates with a mean age of 45 months. The estimated incidence of IPD was 13.6 per 101 children under 5 years old. Diagnoses at presentation were: Pneumonia 63.3% (included 14.3% empyema), bacteremia 17%, meningitis 15.6% (included 2.8% meningitis and pneumonia), 4.1% others. The morbidity rate was 25.2%, mortality rate was 6.1 %. Antibiotic resistance was: Penicillin 44%, ceftriaxone 15%, erythromycin 62%, trimethoprim-sulfamethoxazole 67%. A separate serotype analysis (n = 93, 63%) showed that the current 7valent pneumococcal conjugate vaccine (PCV7) would cover 78.1% of vaccine serotypes and 89% of vaccine-related serotypes for children under 5 years old. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3427 / 3431

页数：5

共 33 条

[11] Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis [J].

Grijalva, Carlos G. ;

Nuorti, J. Pekka ;

Arbogast, Patrick G. ;

Martin, Stacey W. ;

Edwards, Kathryn M. ;

Griffin, Marie R. .

LANCET, 2007, 369 (9568) :1179-1186

[12]

Hausdorff WP, 2005, LANCET INFECT DIS, V5, P83, DOI 10.1016/S1473-3099(05)01280-6

[13] Which pneumococcal serogroups cause the most invasive disease: Implications for conjugate vaccine formulation and use, part I [J].

Hausdorff, WP ;

Bryant, J ;

Paradiso, PR ;

Siber, GR .

CLINICAL INFECTIOUS DISEASES, 2000, 30 (01) :100-121

[14] Invasive pneumococcal disease burden in Hong Kong children [J].

Ho, Pak Leung ;

Chiu, Susan S. ;

Cheung, Chris H. Y. ;

Lee, Rodney ;

Tsai, Theodore F. ;

Lau, Yu Lung .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2006, 25 (05) :454-455

[15]

HO PL, 2004, VACCINE, V4487, P1

[16] Twenty year surveillance of invasive pneumococcal disease in Nottingham: serogroups responsible and implications for immunisation [J].

Ispahani, P ;

Slack, RCB ;

Donald, FE ;

Weston, VC ;

Rutter, N .

ARCHIVES OF DISEASE IN CHILDHOOD, 2004, 89 (08) :757-762

[17] Six year multicenter surveillance of invasive pneumococcal infections in children [J].

Kaplan, SL ;

Mason, EO ;

Wald, ER ;

Tan, TQ ;

Schutze, GE ;

Bradley, JS ;

Givner, LB ;

Kim, KS ;

Yogev, R ;

Barson, WJ .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2002, 21 (02) :141-147

[18]

Koh T. H., 1997, Annals Academy of Medicine Singapore, V26, P604

[19] Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae [J].

Kyaw, MH ;

Lynfield, R ;

Schaffner, W ;

Craig, AS ;

Hadler, J ;

Reingold, A ;

Thomas, AR ;

Harrison, LH ;

Bennett, NM ;

Farley, MM ;

Facklam, RR ;

Jorgensen, JH ;

Besser, J ;

Zell, ER ;

Schuchat, A ;

Whitney, CG .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (14) :1455-1463

[20] Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccine [J].

Lexau, CA ;

Lynfield, R ;

Danila, R ;

Pilishvili, T ;

Facklam, R ;

Farley, MM ;

Harrison, LH ;

Schaffner, W ;

Reingold, A ;

Bennett, NM ;

Hadler, J ;

Cieslak, PR ;

Whitney, CG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (16) :2043-2051

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