Comparative in-vitro activity of penicillin alone and combined with gentamicin against clinical isolates of Streptococcus pneumoniae with decreased susceptibility to penicillin

被引：8

作者：

Anadiotis, L ^{[1
]}

Maskell, JP ^{[1
]}

Sefton, AM ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Dept Med Microbiol, London E1 2AD, England

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2002年 / 19卷 / 03期

关键词：

penicillin-resistance; gentamicin; pneumococci; synergy;

D O I：

10.1016/S0924-8579(01)00495-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The worldwide emergence of Streptococcus pneumoniae with decreased susceptibility to penicillin has led to the suggestion that drug combinations might be used. The aim of this study was to determine possible synergy using a combination of penicillin with sub-inhibitory doses of gentamicin against 26 clinical isolates of S. pneumoniae with decreased susceptibility to penicillin, using half-chequerboards and killing curves, Synergy was demonstrated for ten of the 26 isolates with the combination of penicillin with gentamicin at 1 mg/l and for 22 isolates with penicillin and gentamicin at 2 mg/l. Killing curves on three isolates showed synergy and confirmed the chequerboard results. Further synergy studies using penicillin or cefotaxime/ceftriaxone, plus low dose gentamicin against penicillin-resistant pneumococci are indicated. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：173 / 181

页数：9

共 27 条

[1] Epidemiology and in vitro susceptibility of drug-resistant Streptococcus pneumoniae [J].

Appelbaum, PC .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1996, 15 (10) :932-939

[2] SYNERGISM, KILLING KINETICS, AND ANTI-MICROBIAL SUSCEPTIBILITY OF GROUP-A AND GROUP-B STREPTOCOCCI [J].

BAKER, CN ;

THORNSBERRY, C ;

FACKLAM, RR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1981, 19 (05) :716-725

[3] Synergy between amoxicillin and gentamicin in combination against a highly penicillin-resistant and -tolerant strain of Streptococcus pneumoniae in a mouse pneumonia model [J].

DarrasJoly, C ;

Bedos, JP ;

Sauve, C ;

Moine, P ;

Vallee, E ;

Carbon, C ;

AzoulayDupuis, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (09) :2147-2151

[4] BACTERICIDAL ACTIVITY OF COMBINATIONS OF PENICILLIN OR CLINDAMYCIN WITH GENTAMICIN OR STREPTOMYCIN AGAINST SPECIES OF VIRIDANS STREPTOCOCCI [J].

DUPERVAL, R ;

BILL, NJ ;

GERACI, JE ;

WASHINGTON, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1975, 8 (06) :673-676

[5]

Eliopolous GM., 1996, Antibiotics in laboratory medicine, P330

[6] TIME-KILL STUDIES OF ANTIBIOTIC COMBINATIONS AGAINST PENICILLIN-RESISTANT AND PENICILLIN-SUSCEPTIBLE STREPTOCOCCUS-PNEUMONIAE [J].

FRIEDLAND, IR ;

PARIS, M ;

SHELTON, S ;

MCCRACKEN, GH .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (02) :231-237

[7] Antimicrobial resistance among lower respiratory tract isolates of Streptococcus pneumoniae: Results of a 1992-93 Western Europe and USA collaborative surveillance study [J].

Goldstein, FW ;

Acar, JF .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 38 :71-84

[8] ANTIMICROBIAL ACTIVITIES OF BETA-LACTAM ANTIBIOTICS AND GENTAMICIN AGAINST PENICILLIN-SUSCEPTIBLE AND PENICILLIN-RESISTANT PNEUMOCOCCI [J].

GROSS, ME ;

GIRON, KP ;

SEPTIMUS, JD ;

MASON, EO ;

MUSHER, DM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (05) :1166-1168

[9] ALTERATIONS IN PENICILLIN-BINDING PROTEINS OF CLINICAL AND LABORATORY ISOLATES OF PATHOGENIC STREPTOCOCCUS-PNEUMONIAE WITH LOW-LEVELS OF PENICILLIN RESISTANCE [J].

HANDWERGER, S ;

TOMASZ, A .

JOURNAL OF INFECTIOUS DISEASES, 1986, 153 (01) :83-89

[10]

HANSMAN D, 1967, LANCET, V2, P264

← 1 2 3 →