N-tert-butoxycarbonyl (BOC) deprotection using boron trifluoride etherate

被引：52

作者：

Evans, EF

Lewis, NJ

Kapfer, I

Macdonald, G

Taylor, RJK

机构：

[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,TONBRIDGE TN11 9AN,KENT,ENGLAND

来源：

SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1080/00397919708006783

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOG) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.

引用

收藏

页码：1819 / 1825

页数：7

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