Partial synthesis and biological evaluation of bisbenzylisoquinoline alkaloids derivatives: potential modulators of multidrug resistance in cancer

被引：31

作者：

He, Ping ^{[1
]}

Sun, Hua ^{[2
]}

Jian, Xi-Xian ^{[1
]}

Chen, Qiao-Hong ^{[1
]}

Chen, Dong-Lin ^{[1
]}

Liu, Geng-Tao ^{[2
]}

Wang, Feng-Peng ^{[1
]}

机构：

[1] Sichuan Univ, W China Coll Pharm, Dept Chem Med Nat Prod, Chengdu 610041, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2012年 / 14卷 / 06期

关键词：

bisbenzylisoquinoline alkaloids; multidrug resistance; P-glycoprotein; P-GLYCOPROTEIN; DRUG-RESISTANCE; TUMOR-CELLS; IN-VITRO; TETRANDRINE; REVERSAL; TRANSPORTERS; INHIBITION; CARCINOMA; VIVO;

D O I：

10.1080/10286020.2012.680443

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A series of new bisbenzylisoquinoline alkaloids was partially synthesized from tetrandrine and fangchinoline and evaluated for their ability to reverse P-glycoprotein-mediated multidrug resistance (MDR) in cancer cells. All the test compounds increased the intracellular accumulation rate of rhodamine 123 in MDR cells (Bel7402 and HCT8), and most exhibited more potent MDR-reversing activity relative to the reference compound verapamil. Compounds 8, 10, 13, and 14 enhanced intracellular accumulation of doxorubicin in Bel7402 and HCT8 cells.

引用

页码：564 / 576

页数：13

共 29 条

[1]

Chen LM, 2009, ANTICANCER RES, V29, P4597

[2]

The bisbenzylisoquinoline alkaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance-related drugs via modulation of P-glycoprotein [J].