Novel modes of splicing repression by PTB

被引：122

作者：

Spellman, R ^{[1
]}

Smith, CWJ ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 02期

关键词：

D O I：

10.1016/j.tibs.2005.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polypyrimidine-tract-binding protein (PTB) is a repressive regulator of alternative splicing. Models for PTB activity have ranged from simple binding competition with splicing factor U2AF(65) at regulated polypyrimidine tracts to looping out of repressed exons by binding of PTB to flanking sites. Structural analysis of PTB bound to RNA suggests how PTB monomers can induce loops, but two recent publications indicate that repression by PTB involves more than just binding to RNA.

引用

页码：73 / 76

页数：4

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