p38 MAP kinase: a convergence point in cancer therapy

被引：274

作者：

Olson, JM ^{[1
]}

Hallahan, AR

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[2] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 03期

关键词：

D O I：

10.1016/j.molmed.2004.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies show that activation of p38 mitogen-activated protein kinase (MAPK) results in cancer cell apoptosis initiated by retinoids, cisplatin and other chemotherapeutic agents. The observation that divergent therapies act through a common signal transduction pathway raises the possibility of developing new anti-cancer agents that lack the side-effects caused by events upstream of p38 MAPK. Here, we review p38-MAPK-mediated tumor cell apoptosis and implications for cancer therapeutics.

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收藏

页码：125 / 129

页数：5

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