Enantioselective hydrogenation of α-keto acetals with cinchona modified Pt catalyst

被引：100

作者：

Studer, M ^{[1
]}

Burkhardt, S ^{[1
]}

Blaser, HU ^{[1
]}

机构：

[1] Novartis Serv AG, Sci Serv, CH-4002 Basel, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 17期

关键词：

D O I：

10.1039/a905113i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective hydrogenation of a variety of alpha-keto acetals to the corresponding alpha-hydroxy acetals with Pt catalysts modified with cinchonidine derivatives is described with ees up to 97% and high reaction rates, and the influence of the substrate structure, the modifier and the reaction conditions (catalyst, solvent, temperature, pressure, modifier concentration) was investigated in some detail.

引用

页码：1727 / 1728

页数：2

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