Relation of Heart Rate at Rest and Long-Term (>20 Years) Death Rate in Initially Healthy Middle-Aged Men

被引:136
作者
Jouven, Xavier [1 ,2 ,3 ,4 ]
Empana, Jean Philippe [2 ,3 ,4 ]
Escolano, Sylvie [2 ,3 ,4 ]
Buyck, Jean Francois [2 ,3 ,4 ]
Tafflet, Muriel [2 ,3 ,4 ]
Desnos, Michel [1 ]
Ducimetiere, Pierre [2 ,3 ,4 ]
机构
[1] Hop Europeen Georges Pompidou, Serv Cardiol, Paris, France
[2] Univ Paris 05, Villejuif, France
[3] INSERM, IFR 69, Unite Cardiovasc Epidemiol & Sudden Death 909, Paris Cardiovasc Res Ctr,AP HP,U970, Villejuif, France
[4] Hop Paul Brousse, Villejuif, France
关键词
CORONARY-ARTERY-DISEASE; MYOCARDIAL-INFARCTION; SUDDEN-DEATH; RATE-VARIABILITY; RISK-FACTOR; MORTALITY; ATHEROSCLEROSIS; ASSOCIATION; POPULATION; PREDICTOR;
D O I
10.1016/j.amjcard.2008.08.071
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The prognostic implications of heart rate (HR) change over years have never been assessed. It was hypothesized that an increase in HR in apparently healthy persons observed over years could be associated with an increase in mortality risk and conversely. A total of 5,139 asymptomatic working men (aged 42 to 53 years) free of clinically detectable cardiovascular disease were recruited from 1967 to 1972 and had their HRs measured at rest in standardized conditions every year for 5 consecutive years. HR change was defined as the difference between HR at examination 5 and HR at inclusion, and subjects were divided into tertiles according to decrease >4 beats/min, unchanged (from -4 to +3 beats/min), and increase >3 beats/min. After >20 years of mortality surveillance, 1,219 deaths were observed. After adjustments were made for confounding factors, including baseline HR at rest, and compared with subjects with unchanged HRs, subjects with decreased HRs during the 5 years had a 14% decreased mortality risk (RR 0.86, 95% confidence interval 0.74 to 1.00, p = 0.05), whereas subjects with increased HRs during the 5 years had a 19% increased mortality risk (RR 1.19, and 95% confidence interval 1.04 to 1.37, p <0.012). In conclusion, change in HR at rest over 5 years was an independent predictor of mortality in middle-aged men. (c) 2009 Published by Elsevier Inc. (Am J Cardiol 2009;103:279-283)
引用
收藏
页码:279 / 283
页数:5
相关论文
共 27 条
[21]  
Levy M. N., 1984, PHYSL PATHOPHYSIOLOG, P337, DOI [10.1007/978-1-4757-1171-4_15, DOI 10.1007/978-1-4757-1171-4_15]
[22]   Heart rate: a strong predictor of mortality in subjects with coronary artery disease [J].
Palatini, P .
EUROPEAN HEART JOURNAL, 2005, 26 (10) :943-945
[23]   High heart rate - A risk factor for cardiovascular death in elderly men [J].
Palatini, P ;
Casiglia, E ;
Julius, S ;
Pessina, AC .
ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (06) :585-592
[24]   MINIMUM HEART-RATE AND CORONARY ATHEROSCLEROSIS - INDEPENDENT RELATIONS TO GLOBAL SEVERITY AND RATE OF PROGRESSION OF ANGIOGRAPHIC LESIONS IN MEN WITH MYOCARDIAL-INFARCTION AT A YOUNG AGE [J].
PERSKI, A ;
OLSSON, G ;
LANDOU, C ;
DEFAIRE, U ;
THEORELL, T ;
HAMSTEN, A .
AMERICAN HEART JOURNAL, 1992, 123 (03) :609-616
[25]  
RANDALL W C, 1977, P440
[26]   Association of socioeconomic status with functional capacity, heart rate recovery, and all-cause mortality [J].
Shishehbor, MH ;
Litaker, D ;
Pothier, CE ;
Lauer, MS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (07) :784-792
[27]  
WATANABE AM, 1984, PHYSL PATHOPHYSIOLOG, P354