Increased VWF antigen levels and decreased ADAMTS13 activity in preeclampsia

被引：71

作者：

Aref, Salah ^{[1
]}

Goda, Hosam ^{[2
]}

机构：

[1] Mansoura Fac Med, Hematol Unit, Dept Clin Pathol, Mansoura, Egypt

[2] Mansoura Fac Med, Obstet & Gynacol Dept, Mansoura, Egypt

来源：

HEMATOLOGY | 2013年 / 18卷 / 04期

关键词：

ADAMTS13; Preeclampsia (PE); VWF; VON-WILLEBRAND-FACTOR; FACTOR PROPEPTIDE; PATHOPHYSIOLOGY; ACTIVATION; PREGNANCY; PLATELETS; COMPLEX;

D O I：

10.1179/1607845412Y.0000000070

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

This study aimed to assess the von Willebrand factor (VWF) antigen levels and its proteolytic enzyme ADAMTS13 activity in preeclampsia. The study includes 10 non-pregnant women, 50 normal pregnancy, and 110 preeclamptic (PE) women at the same period of pregnancy. For all studied groups plasma ADAMTS13 activities were determined with the FRETs-VWF 73 assay, while VWF antigen levels with an immunoturbometric assay. The plasma ADAMTS13 activity was significantly reduced in PE as compared with normal pregnancy and non-pregnant women (P < 0.01 for both). In contrast, plasma VWF antigen and VWF RCO were significantly elevated in PE, as compared with normal pregnancy group as well as non-pregnant women (P < 0.01 for both). In conclusion, reduction of plasma ADAMTS13 and elevation in VWF might have a role in the pathogenesis of PE.

引用

页码：237 / 241

页数：5

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