Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae

被引：38

作者：

Kim, YS

Liu, QX

Chow, LL

Tauber, MG

机构：

[1] UNIV CALIF SAN FRANCISCO, SAN FRANCISCO GEN HOSP, INFECT DIS LAB, SAN FRANCISCO, CA 94143 USA

[2] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA

[3] UNIV CALIF SAN FRANCISCO, DEPT NEUROL, SAN FRANCISCO, CA 94143 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 05期

关键词：

D O I：

10.1128/AAC.41.5.1186

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The fluoroquinolone trovafloxacin was bactericidal (0.47 +/- 0.23 Delta log(10) CFU/ml h after 10 mg/kg of body weight and 0.78 +/- 0.15 Delta log(10) CFU/ml h after 30 mg/kg) in the treatment of experimental meningitis caused by a highly penicillin-resistant (MlC and minimum bactericidal concentration = 4 and 4 mu g/ml) strain of Streptococcus pneumoniae. Combinations with ampicillin and rifampin were indifferent compared to single drugs.

引用

页码：1186 / 1189

页数：4

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