Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae

被引：38

作者：

Kim, YS

Liu, QX

Chow, LL

Tauber, MG

机构：

[1] UNIV CALIF SAN FRANCISCO, SAN FRANCISCO GEN HOSP, INFECT DIS LAB, SAN FRANCISCO, CA 94143 USA

[2] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA

[3] UNIV CALIF SAN FRANCISCO, DEPT NEUROL, SAN FRANCISCO, CA 94143 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 05期

关键词：

D O I：

10.1128/AAC.41.5.1186

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The fluoroquinolone trovafloxacin was bactericidal (0.47 +/- 0.23 Delta log(10) CFU/ml h after 10 mg/kg of body weight and 0.78 +/- 0.15 Delta log(10) CFU/ml h after 30 mg/kg) in the treatment of experimental meningitis caused by a highly penicillin-resistant (MlC and minimum bactericidal concentration = 4 and 4 mu g/ml) strain of Streptococcus pneumoniae. Combinations with ampicillin and rifampin were indifferent compared to single drugs.

引用

页码：1186 / 1189

页数：4

共 26 条

[11] TREATMENT FAILURE WITH USE OF A 3RD-GENERATION CEPHALOSPORIN FOR PENICILLIN-RESISTANT PNEUMOCOCCAL MENINGITIS - CASE-REPORT AND REVIEW
JOHN, CC
[J]. CLINICAL INFECTIOUS DISEASES, 1994, 18 (02) : 188 - 193
[12] KLUGMAN KP, 1989, LANCET, V2, P444
[13] ANTIMICROBIAL THERAPY OF EXPERIMENTAL MENINGITIS CAUSED BY STREPTOCOCCUS-PNEUMONIAE STRAINS WITH DIFFERENT SUSCEPTIBILITIES TO PENICILLIN
MCCRACKEN, GH
SAKATA, Y
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (02) : 141 - 145
[14] INTERCONTINENTAL SPREAD OF A MULTIRESISTANT CLONE OF SEROTYPE-23F STREPTOCOCCUS-PNEUMONIAE
MUNOZ, R
COFFEY, TJ
DANIELS, M
DOWSON, CG
LAIBLE, G
CASAL, J
HAKENBECK, R
JACOBS, M
MUSSER, JM
SPRATT, BG
TOMASZ, A
[J]. JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (02) : 302 - 306
[15] QUINOLONE ANTIBIOTICS IN THERAPY OF EXPERIMENTAL PNEUMOCOCCAL MENINGITIS IN RABBITS
NAU, R
SCHMIDT, T
KAYE, K
FROULA, JL
TAUBER, MG
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (03) : 593 - 597
[16] RIFAMPIN FOR THERAPY OF EXPERIMENTAL PNEUMOCOCCAL MENINGITIS IN RABBITS
NAU, R
KAYE, K
SACHDEVA, M
SANDE, ER
TAUBER, MG
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (05) : 1186 - 1189
[17] EVALUATION OF CP-99,219, A NEW FLUOROQUINOLONE, FOR TREATMENT OF EXPERIMENTAL PENICILLIN-RESISTANT AND CEPHALOSPORIN-RESISTANT PNEUMOCOCCAL MENINGITIS
PARIS, MM
HICKEY, SM
TRUJILLO, M
SHELTON, S
MCCRACKEN, GH
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (06) : 1243 - 1246
[18] MANAGEMENT OF MENINGITIS CAUSED BY PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE
PARIS, MM
RAMILO, O
MCCRACKEN, GH
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (10) : 2171 - 2175
[19] *PFIZ INC, 1996, MAN INF
[20] SCHELD WM, 1989, REV INFECT DIS, V11, pS1194

← 1 2 3 →