Choriodecidual infection and preterm birth

被引:98
作者
Goldenberg, RL [1 ]
Andrews, WW [1 ]
Hauth, JC [1 ]
机构
[1] Univ Alabama Birmingham, Dept Obstet & Gynecol, Birmingham, AL 35249 USA
关键词
D O I
10.1301/00296640260130696
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Of all U.S. births, 11% occur preterm. These infants are responsible for the majority of perinatal mortality and morbidity. Infants at highest risk are those born weighing <1000 g and those born at <28 weeks gestation. Recent evidence suggests that the majority of these preterm births are caused by bacterial infections of the chorioamnion, with the organisms originating in the vagina. The mechanisms leading to preterm labor and rupture of membranes involve an inflammatory response involving increased production of cytokines, prostaglandins, and metalloproteases. Results of treatment trials to eradicate the infection and reduce preterm birth have been mixed. (C) 2002 International Life Sciences Institute.
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收藏
页码:S19 / S25
页数:7
相关论文
共 76 条
[61]   ELEVATION OF AMNIOTIC-FLUID INTERLEUKIN-6 (IL-6), IL-8 AND GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF) IN TERM AND PRETERM PARTURITION [J].
SAITO, S ;
KASAHARA, T ;
KATO, Y ;
ISHIHARA, Y ;
ICHIJO, M .
CYTOKINE, 1993, 5 (01) :81-88
[62]   HUMAN PLACENTA CONSTITUTIVELY PRODUCES INTERLEUKIN-8 DURING PREGNANCY AND ENHANCES ITS PRODUCTION IN INTRAUTERINE INFECTION [J].
SHIMOYA, K ;
MATSUZAKI, N ;
TANIGUCHI, T ;
KAMEDA, T ;
KOYAMA, M ;
NEKI, R ;
SAJI, F ;
TANIZAWA, O .
BIOLOGY OF REPRODUCTION, 1992, 47 (02) :220-226
[63]   EVIDENCE RELATING BACTERIAL VAGINOSIS TO INTRAAMNIOTIC INFECTION [J].
SILVER, HM ;
SPERLING, RS ;
STCLAIR, PJ ;
GIBBS, RS .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1989, 161 (03) :808-812
[64]   Immunmodulating cytokines induce term and preterm parturition [J].
Steinborn, A ;
Kuhnert, M ;
Halberstadt, E .
JOURNAL OF PERINATAL MEDICINE, 1996, 24 (04) :381-390
[65]   Ampicillin-metronidazole treatment in idiopathic preterm labour: A randomised controlled multicentre trial [J].
Svare, J ;
LanghoffRoos, J ;
Andersen, LF ;
KrygerBaggesen, N ;
BorchChristensen, H ;
Heisterberg, L ;
Kristensen, J .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1997, 104 (08) :892-897
[66]   Interleukin-1β and interleukin-8 in cervicovaginal fluid during pregnancy [J].
Tanaka, Y ;
Narahara, H ;
Takai, N ;
Yoshimatsu, J ;
Anai, T ;
Miyakawa, I .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1998, 179 (03) :644-649
[67]   PRENATAL AND PERINATAL FACTORS IN THE ETIOLOGY OF CEREBRAL-PALSY [J].
TORFS, CP ;
VANDENBERG, BJ ;
OECHSLI, FW ;
CUMMINS, S .
JOURNAL OF PEDIATRICS, 1990, 116 (04) :615-619
[68]  
TUCKER JM, 1991, OBSTET GYNECOL, V77, P343
[69]  
VENTURA SJ, 1996, MON VITAL STAT REP S, V44, P75
[70]   Prophylactic administration of clindamycin 2% vaginal cream to reduce the incidence of spontaneous preterm birth in women with an increased recurrence risk: a randomised placebo-controlled double-blind trial [J].
Vermeulen, GM ;
Bruinse, HW .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1999, 106 (07) :652-657