Systemic elevation of interleukin-15 in vivo promotes apoptosis in skeletal muscles of young adult and aged rats

被引：37

作者：

Pistilli, Emidio E. ^{[1
,2
]}

Alway, Stephen E. ^{[1
]}

机构：

[1] W Virginia Univ, Sch Med, Div Exercise Physiol, Lab Muscle Biol & Sarcopenia, Morgantown, WV 26506 USA

[2] Univ Penn, Dept Physiol, Penn Muscle Inst, Philadelphia, PA 19104 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 373卷 / 01期

关键词：

interleukins; aging; sarcopenia; apoptosis;

D O I：

10.1016/j.bbrc.2008.05.188

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In this study, we tested the hypothesis that systemic elevation of IL-15 would attenuate apoptosis in skeletal muscles of aged rats. IL-15 was administered to young adult (n = 6) and aged (n = 6) rats for 14 days. Apoptosis was quantified using an ELISA assay and verified through TUNEL staining of muscle sections. As expected, apoptosis was greater in muscles from aged control rats, compared to age-matched control. Apoptosis was also greater in the muscles from young adult and aged rats treated with IL-15. These increases in apoptosis were associated with decreases in muscle mass of IL-15 treated rats. These data do not support our initial hypothesis and suggest that systemic elevation of IL-15 promotes apoptosis in skeletal muscle. The proposed anti-apoptotic property of IL-15 may be specific to cell-type and/or the degree of muscle pathology present; however, additional research is required to more clearly decipher its role in skeletal muscle. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：20 / 24

页数：5

共 28 条

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