Distribution of bending propensity in DNA sequences

被引：48

作者：

Gabrielian, A

Simoncsits, A

Pongor, S

机构：

[1] INT CTR GENET ENGN & BIOTECHNOL,AREA SCI PK,I-34012 TRIESTE,ITALY

[2] RUSSIAN ACAD SCI,INST MOL BIOL,MOSCOW 117984,RUSSIA

来源：

FEBS LETTERS | 1996年 / 393卷 / 01期

关键词：

bendability; DNase I cleavage;

D O I：

10.1016/0014-5793(96)00837-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Local bending propensity and curvature of DNA can be characterized using a vector description of DNA bendability, based on a set of parameters derived from deoxyribonoclease I (DNase I) cleavage experiments. Two characteristics - arithmetic and vector averages of bendability - were successfully used to predict experimentally known bendable, rigid and curved segments in DNA. A characteristic distribution of bendability is conserved in evolutionarily related kinetoplast sequences. An analysis of the M. genitalium and H. influenzae genomes as well as fragments of human and yeast genomes shows, on the other hand, that highly curved segments - similar to artificially designed curved oligonucleotides - are extremely rare in natural DNA.

引用

收藏

页码：124 / 130

页数：7

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