Brain mechanisms of pain affect and pain modulation

被引：438

作者：

Rainville, P ^{[1
]}

机构：

[1] Univ Montreal, Fac Med Dent, Dept Stomatol, Montreal, PQ H3C 3J7, Canada

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0959-4388(02)00313-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent animal studies reveal ascending nociceptive and descending modulatory pathways that may contribute to the affective-motivational aspects of pain and play a critical role in the modulation of pain. In humans, a reliable pattern of cerebral activity occurs during the subjective experience of pain. Activity within the anterior cingulate cortex and possibly in other classical limbic structures, appears to be closely related to the subjective experience of pain unpleasantness and may reflect the regulation of endogenous mechanisms of pain modulation.

引用

收藏

页码：195 / 204

页数：10

相关论文

共 95 条

[61] Reduction in opioid- and cannabinoid-induced antinociception in rhesus monkeys after bilateral lesions of the amygdaloid complex [J].

Manning, BH ;

Merin, NM ;

Meng, ID ;

Amaral, DG .

JOURNAL OF NEUROSCIENCE, 2001, 21 (20) :8238-8246

[62] FOREBRAIN PROJECTIONS TO THE PERIAQUEDUCTRAL GRAY IN THE MONKEY, WITH OBSERVATIONS IN THE CAT AND RAT [J].

MANTYH, PW .

JOURNAL OF COMPARATIVE NEUROLOGY, 1982, 206 (02) :146-158

[63] An analgesia circuit activated by cannabinoids [J].

Meng, ID ;

Manning, BH ;

Martin, WJ ;

Fields, HL .

NATURE, 1998, 395 (6700) :381-383

[64] Ventromedial thalamic neurons convey nociceptive signals from the whole body surface to the dorsolateral neocortex [J].

Monconduit, L ;

Bourgeais, L ;

Bernard, JF ;

Le Bars, D ;

Villanueva, L .

JOURNAL OF NEUROSCIENCE, 1999, 19 (20) :9063-9072

[65] Primate anterior cingulate cortex: Where motor control, drive and cognition interface [J].

Paus, T .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (06) :417-424

[66]

Paus T, 2000, PROG BRAIN RES, V126, P65

[67] Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies [J].

Paus, T ;

Koski, L ;

Caramanos, Z ;

Westbury, C .

NEUROREPORT, 1998, 9 (09) :R37-R47

[68] ROLE OF THE HUMAN ANTERIOR CINGULATE CORTEX IN THE CONTROL OF OCULOMOTOR, MANUAL, AND SPEECH RESPONSES - A POSITRON EMISSION TOMOGRAPHY STUDY [J].

PAUS, T ;

PETRIDES, M ;

EVANS, AC ;

MEYER, E .

JOURNAL OF NEUROPHYSIOLOGY, 1993, 70 (02) :453-469

[69] Expression of mu, kappa, and delta opioid receptor messenger RNA in the human CNS:: A 33P in situ hybridization study [J].

Peckys, D ;

Landwehrmeyer, GB .

NEUROSCIENCE, 1999, 88 (04) :1093-1135

[70] Placebo and opioid analgesia - Imaging a shared neuronal network [J].

Petrovic, P ;

Kalso, E ;

Petersson, KM ;

Ingvar, M .

SCIENCE, 2002, 295 (5560) :1737-1740

← 1 2 3 4 5 6 7 8 9 10 →