Antiplatelet therapy in cardiovascular disease

被引:33
作者
Behan, MWH
Storey, RF
机构
[1] Univ Nottingham Hosp, Div Cardiovasc Med, Nottingham NG7 2UH, England
[2] No Gen Hosp, Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, England
关键词
D O I
10.1136/pgmj.2003.007062
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Platelet activation and aggregation are considered to be central to arterial thrombus formation. Antiplatelet therapy is therefore important for both the treatment and prevention of cardiovascular disease. Aspirin, the most widely used antiplatelet agent, inhibits platelet cyclo-oxygenase and the conversion of arachidonic acid to the potent platelet agonist thromboxane A(2) but does not prevent platelet activation occurring via various signalling pathways that are independent of thromboxane A(2) release. Therefore a number of other compounds have been developed to complement aspirin's beneficial effect. These include the thienopyridines (clopidogrel and ticlopidine), dipyridamole, and the alpha(IIb)beta(3) (glycoprotein IIb/IIIa) receptor inhibitors.
引用
收藏
页码:155 / 164
页数:10
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