A new inflammatory cytokine on the block: Re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17

被引:251
作者
Gaffen, S. L. [1 ,2 ]
Hajishengallis, G. [3 ,4 ]
机构
[1] SUNY Buffalo, Sch Dent Med, Dept Oral Biol, Buffalo, NY 14214 USA
[2] SUNY Buffalo, Sch Med & Biomed Sci, Dept Microbiol & Immunol, Buffalo, NY 14214 USA
[3] Univ Louisville, Hlth Sci Ctr, Dept Periodont Oral Hlth & Syst Dis, Louisville, KY 40292 USA
[4] Univ Louisville, Hlth Sci Ctr, Dept Microbiol & Immunol, Louisville, KY 40292 USA
关键词
cytokines; Th1/Th2/Th17; IL-17; periodontal disease;
D O I
10.1177/154405910808700908
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
For almost two decades, the Th1/Th2 paradigm has offered a productive conceptual framework for investigating the pathogenesis of periodontitis. However, as with many other inflammatory diseases, the observed role of T-cell-mediated immunity in periodontitis did not readily fit this model. A new subset of CD4+ T-cells was recently discovered that explains many of the discrepancies in the classic Th1/Th2 model, and has been termed "Th17" based on its secretion of the novel proinflammatory cytokine IL-17. The identification of Th17 cells as a novel effector T-cell population compels re-examination of periodontitis in the context of the new subset and its signature cytokines. This review aims to offer a clarifying insight into periodontal pathogenesis under the extended Th1/Th2/Th17 paradigm, and is predicated on the principle that periodontal disease activity is determined by a complex interplay between the immune system and periodontal pathogens. The re-examination of existing periodontal literature and further studies in the light of these new discoveries may help explain how the inflammatory response results in damage to the periodontium while generally failing to control the pathogens. This knowledge is essential for the development of immunomodulatory intervention strategies for fine-tuning the host response to maximize the protective and minimize the destructive aspects of the periodontal host response. Moreover, with the advent of anti-cytokine biologic drugs that target the Th1 and Th17 pathways in autoimmunity, the potential consequences to periodontal disease susceptibility in humans need to be understood. Abbreviations: CIA, collagen-induced arthritis; CMI, cell-mediated immunity; DC, dendritic cell; EAE, experimental autoimmune encephalomyelitis; ERK, extracellular signal-regulated kinase; IL-, interleukin; IRF, interferon regulatory factor; KO, knockout; PGE2, prostaglandin E2; PRR, pattern-recognition receptor; ROR, retinoic acid receptor; TCR, T-cell receptor; Th, T helper; TLR, Toll-like receptor; TRIF, TIR-domain-containing adapter protein-inducing interferon-beta.
引用
收藏
页码:817 / 828
页数:12
相关论文
共 172 条
[81]  
KOLLOCH RE, 2004, PERFUSION-GERMANY, V17, P467
[82]  
Kolls JK, 2005, NEW ENGL J MED, V352, P627
[83]   IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells [J].
Korn, Thomas ;
Bettelli, Estelle ;
Gao, Wenda ;
Awasthi, Amit ;
Jaeger, Anneli ;
Strom, Terry B. ;
Oukka, Mohamed ;
Kuchroo, Vijay K. .
NATURE, 2007, 448 (7152) :484-U9
[84]   IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis [J].
Kotake, S ;
Udagawa, N ;
Takahashi, N ;
Matsuzaki, K ;
Itoh, K ;
Ishiyama, S ;
Saito, S ;
Inoue, K ;
Kamatani, N ;
Gillespie, MT ;
Martin, TJ ;
Suda, T .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (09) :1345-1352
[85]   Interleukin-17: A new paradigm in inflammation, autoimmunity, and therapy [J].
Kramer, Jill M. ;
Gaffen, Sarah L. .
JOURNAL OF PERIODONTOLOGY, 2007, 78 (06) :1083-1093
[86]   Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F [J].
Kuestner, Rolf E. ;
Taft, David W. ;
Haran, Aaron ;
Brandt, Cameron S. ;
Brender, Ty ;
Lum, Karen ;
Harder, Brandon ;
Okada, Shannon ;
Ostrander, Craig D. ;
Kreindler, James L. ;
Aujla, Shean J. ;
Reardon, Brian ;
Moore, Margaret ;
Shea, Pamela ;
Schreckhise, Randall ;
Bukowski, Thomas R. ;
Presnell, Scott ;
Guerra-Lewis, Patricia ;
Parrish-Novak, Julia ;
Ellsworth, Jeff L. ;
Jaspers, Stephen ;
Lewis, Katherine E. ;
Appleby, Mark ;
Kolls, Jay K. ;
Rixon, Mark ;
West, James W. ;
Gao, Zeren ;
Levin, Steven D. .
JOURNAL OF IMMUNOLOGY, 2007, 179 (08) :5462-5473
[87]   IL-23 drives a pathogenic T cell population that induces autoimmune inflammation [J].
Langrish, CL ;
Chen, Y ;
Blumenschein, WM ;
Mattson, J ;
Basham, B ;
Sedgwick, JD ;
McClanahan, T ;
Kastelein, RA ;
Cua, DJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :233-240
[88]   Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue [J].
Lappin, DF ;
Macleod, CP ;
Kerr, A ;
Mitchell, T ;
Kinane, DF .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2001, 123 (02) :294-300
[89]   TH-17 differentiation:: of mice and men [J].
Laurence, Arian ;
O'Shea, John J. .
NATURE IMMUNOLOGY, 2007, 8 (09) :903-905
[90]   Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation [J].
Laurence, Arian ;
Tato, Cristina M. ;
Davidson, Todd S. ;
Kanno, Yuka ;
Chen, Zhi ;
Yao, Zhengju ;
Blank, Rebecca B. ;
Meylan, Francoise ;
Siegel, Richard ;
Hennighausen, Lothar ;
Shevach, Ethan M. ;
O'Shea, John J. .
IMMUNITY, 2007, 26 (03) :371-381