Automated production of 16α-[18F]fluoroestradiol for breast cancer imaging

被引：44

作者：

Römer, J ^{[1
]}

Füchtner, F ^{[1
]}

Steinbach, J ^{[1
]}

Johanssen, B ^{[1
]}

机构：

[1] Rossendorf Inc, Forschungszentrum Rossendorf EV, Inst Bioanorgan & Radiopharmazeut Chem, D-01314 Dresden, Germany

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1999年 / 26卷 / 04期

关键词：

D O I：

10.1016/S0969-8051(98)00098-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The results show that it was possible to apply the safe and reproducible process of preparation of chemically and radiochemically pure 16α-[18F]FES to an automatic module. The modified [18F]FDG module from Nuclear Interface proved to be suitable for this method. An automatic module and a production plant make it possible to work with an amount of radioactivity of up to 100 GBq. Thus, there is nothing to impede the regular production of 16α- [18F]FES as a radiopharmaceutical in amounts that permit application to several breast cancer patients.

引用

页码：473 / 479

页数：7

共 10 条

[1]

KIESEWETTER DO, 1984, J NUCL MED, V25, P1212

[2] SYNTHESIS OF 16-FLUOROESTROGENS BY UNUSUALLY FACILE FLUORIDE-ION DISPLACEMENT-REACTIONS - PROSPECTS FOR THE PREPARATION OF F-18 LABELED ESTROGENS [J].

KIESEWETTER, DO ;

KATZENELLENBOGEN, JA ;

KILBOURN, MR ;

WELCH, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (25) :4900-4905

[3] The use of 3-methoxymethyl-16 beta,17 beta-epiestriol-O-cyclic sulfone as the precursor in the synthesis of F-18 16 alpha-fluoroestradiol [J].

Lim, JL ;

Zheng, L ;

Berridge, MS ;

Tewson, TJ .

NUCLEAR MEDICINE AND BIOLOGY, 1996, 23 (07) :911-915

[4]

Lim JL, 1993, 10 INT S RAD CHEM KY

[5]

MAGNI F, 1992, APPL RADIAT ISOTOPES, V43, P1299

[6]

MCGUIRE AH, 1991, J NUCL MED, V32, P1526

[7] BREAST-CANCER - PET IMAGING OF ESTROGEN-RECEPTORS [J].

MINTUN, MA ;

WELCH, MJ ;

SIEGEL, BA ;

MATHIAS, CJ ;

BRODACK, JW ;

MCGUIRE, AH ;

KATZENELLENBOGEN, JA .

RADIOLOGY, 1988, 169 (01) :45-48

[8] Studies on the synthesis of 16 alpha-[F-18]fluoroestradiol [J].

Romer, J ;

Steinbach, J ;

Kasch, H .

APPLIED RADIATION AND ISOTOPES, 1996, 47 (04) :395-399

[9]

TEWSON TJ, 1983, J NUCL MED, V24, pP52

[10]

TEWSON TJ, 1995, 11 INT S RAD CHEM VA

← 1 →