Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development

被引：11

作者：

Takasato, Minoru ^{[1
,2
]}

Kobayashi, Chiyoko ^{[1
]}

Okabayashi, Koji ^{[2
]}

Kiyonari, Hiroshi ^{[3
]}

Oshima, Naoko ^{[3
]}

Asashima, Makoto ^{[2
]}

Nishinakamura, Ryuichi ^{[1
]}

机构：

[1] Kumamoto Univ, Div Integrat Cell Biol, Inst Mol Embryol & Genet, Kumamoto 8600811, Japan

[2] Univ Tokyo, Dept Life Sci Biol, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

[3] RIKEN, Lab Anim Resources & Genet Engn, Ctr Dev Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 373卷 / 04期

基金：

日本学术振兴会;

关键词：

Trb2; tribbles; Sall1; notch; kidney; mesenchymal gene; metanephric mesenchyme; podocyte; knockout; development;

D O I：

10.1016/j.bbrc.2008.06.088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glomeruli comprise an important filtering apparatus in the kidney and are derived from the metanephric mesenchyme. A nuclear protein, Sall1, is expressed in this mesenchyme, and we previously reported that Trb2, a mouse homolog of Drosophila tribbles, is expressed in the mesenchyme-derived tissues of the kidney by microarray analyses using Sall1-GFP knock-in mice. In the present report, we detected Trb2 expression in a variety of organs during gestation, including the kidneys, mesonephros, testes, heart, eyes, thymus, blood vessels, muscle, bones, tongue, spinal cord, and ganglions. In the developing kidney, Trb2 signals were detected in podocytes and the prospective mesangium of the glomeruli, as well as in ureteric bud tips. However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：648 / 652

页数：5

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