Dissociation of automatic and strategic lexical-semantics: Functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions

被引:248
作者
Gold, Brian T. [1 ]
Balota, David A.
Jones, Sara J.
Powell, David K.
Smith, Charles D.
Andersen, Anders H.
机构
[1] Univ Kentucky, Sch Med, Dept Anat & Neurobiol, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA
[3] Univ Kentucky, Magnet Resonance & Spectroscopy Ctr, Chandler Med Ctr, Lexington, KY 40536 USA
[4] Washington Univ, Dept Psychol, St Louis, MO 63130 USA
关键词
language; fMRI; lexical; semantics; word recognition; priming;
D O I
10.1523/JNEUROSCI.0808-06.2006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Behavioral research has demonstrated three major components of the lexical-semantic processing system: automatic activation of semantic representations, strategic retrieval of semantic representations, and inhibition of competitors. However, these component processes are inherently conflated in explicit lexical-semantic decision tasks typically used in functional magnetic resonance imaging (fMRI) research. Here, we combine the logic of behavioral priming studies and the neurophysiological phenomenon of fMRI priming to dissociate the neural bases of automatic and strategic lexical-semantic processes across a series of three studies. A single lexical decision task was used in all studies, with stimulus onset asynchrony or linguistic relationship between prime and target being manipulated. Study 1 demonstrated automatic semantic priming in the left mid-fusiform gyrus (mid-FFG) and strategic semantic priming in five regions: left middle temporal gyrus (MTG), bilateral anterior cingulate, anterior left inferior prefrontal cortex (aLIPC), and posterior LIPC (pLIPC). These priming effects were explored in more detail in two subsequent studies. Study 2 replicated the automatic priming effect in mid-FFG and demonstrated that automatic priming in this region is preferential for the semantic domain. Study 3 demonstrated a neural dissociation in regions contributing to the strategic semantic priming effect. Strategic semantic facilitation was observed in the aLIPC and MTG, whereas strategic semantic inhibition was observed in the pLIPC and anterior cingulate. These studies provide reproducible evidence for a neural dissociation between three well established components of the lexical-semantic processing system.
引用
收藏
页码:6523 / 6532
页数:10
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