A charge-modulated FET for detection of biomolecular processes: Conception, modeling, and simulation

被引：141

作者：

Barbaro, M ^{[1
]}

Bonfiglio, A

Raffo, L

机构：

[1] Univ Cagliari, Dept Elect & Elect Engn, I-09123 Cagliari, Italy

[2] Consorzio Nazl Interuniv Sci Mat, I-90123 Palermo, Italy

[3] CNR, INFM, S3, Modena, Italy

来源：

IEEE TRANSACTIONS ON ELECTRON DEVICES | 2006年 / 53卷 / 01期

关键词：

charge sensor; DNA detection; DNA-chip; field-effect transistor (FET) sensor; micro-arrays;

D O I：

10.1109/TED.2005.860659

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A novel, solid-state sensor for charge detection in biomolecular processes is proposed. The device, called charge-modulated field-effect transistor, is compatible with a standard CMOS process, thus allowing fully electronic readout and large scale of integration of biosensors on a single chip. The detection mechanism is based on the field-effect modulation induced by electric charge changes related to the bioprocess. A model of the device was developed, to provide a manageable relationship between its output and geometric, design and process parameters. Extensive two- and three-dimensional simulations of the proposed structure validated the model and the working principle.

引用

页码：158 / 166

页数：9