EFFECTS OF REPEATED ABOBOTULINUMTOXINA INJECTIONS IN UPPER LIMB SPASTICITY

被引：46

作者：

Gracies, Jean-Michel ^{[1
]}

O'Dell, Michael ^{[2
]}

Vecchio, Michele ^{[3
]}

Hedera, Peter ^{[4
]}

Kocer, Serdar ^{[5
]}

Rudzinska-Bar, Monika ^{[6
]}

Rubin, Bruce ^{[7
]}

Timerbaeva, Sofiya L. ^{[8
]}

Lusakowska, Anna ^{[9
]}

Boyer, Francois Constant ^{[10
,11
]}

Grandoulier, Anne-Sophie ^{[12
]}

Vilain, Claire ^{[12
]}

Picaut, Philippe ^{[12
]}

机构：

[1] Univ Paris Est Creteil, Hop Univ Henri Mondor, Serv Reeduc Neurolocomotrice, EA BIOTN 7377, 51 Ave Marechal De Lattre De Tassigny, F-94010 Creteil, France

[2] Weill Cornell Med, Dept Rehabil Med, Baker Pavil, New York, NY USA

[3] Policlin Vittorio Emanuele Univ Hosp, Dept UO Phys Med & Rehabil, Catania, Italy

[4] Vanderbilt Univ, Div Movement Disorders, Dept Neurol, 221 Kirkland Hall, Nashville, TN 37235 USA

[5] Hop Jura, Ctr Reeduc, Porrentruy, Switzerland

[6] Med Univ Silesia, Dept Neurol, Fac Med, Katowice, Poland

[7] Design Neurosci Ctr, Doral, FL USA

[8] Res Ctr Neurol, Moscow, Russia

[9] Med Univ Warsaw, Dept Neurol, Warsaw, Poland

[10] Hop Univ Sebastopol, Unit Med Phys, EA 3797, Champagne Ardenne, France

[11] Hop Univ Sebastopol, Unit Readaptat, EA 3797, Champagne Ardenne, France

[12] Ipsen Innovat, Les Ulis, France

来源：

MUSCLE & NERVE | 2018年 / 57卷 / 02期

关键词：

active function; botulinum toxin; open label; stroke; traumatic brain injury; upper limb spasticity; MYASTHENIA-GRAVIS; NERVE-STIMULATION; OUTCOME MEASURE; VALIDATION; MUSCLE; SCALE; RELIABILITY;

D O I：

10.1002/mus.25721

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Introduction: The efficacy of single injections of abobo-tulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500-U dose included 500-U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment-emergent adverse events (TEAEs), muscle tone, passive and active range of motion (XV1, XA), angle of catch (XV3), Disability Assessment Scale (DAS) score, Modified Frenchay Scale (MFS) score, and Physician Global Assessment (PGA) score. Results: The incidence of TEAEs decreased across cycles. Muscle tone reduction and XV1 remained stable across cycles, whereas XV3 and XA continued to improve at the finger, wrist, and elbow flexors. DAS and PGA improved across cycles. MFS improved best with 1,500 U. Discussion: A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limbmuscles.

引用

页码：245 / 254

页数：10

共 23 条

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