VALIDATION OF THE BESTA NEUROLOGICAL INSTITUTE RATING SCALE FOR MYASTHENIA GRAVIS

被引：15

作者：

Antozzi, Carlo ^{[1
]}

Brenna, Greta ^{[1
]}

Baggi, Fulvio ^{[1
]}

Camera, Giorgia ^{[1
]}

Maggi, Lorenzo ^{[1
]}

Rezzani, Cristiana ^{[2
]}

Montomoli, Cristina ^{[2
]}

Mantegazza, Renato ^{[1
]}

机构：

[1] Fdn IRCCS Ist Nazl Neurol C Besta, UO Neurol Neuroimmunol & Malattie Neuromuscolari, I-20133 Milan, Italy

[2] Univ Pavia, Dipartimento Sanita Pubbl Med Sperimentale & Fore, Unita Biostat & Epidemiol Clin, I-27100 Pavia, Italy

来源：

MUSCLE & NERVE | 2016年 / 53卷 / 01期

关键词：

disability; Myasthenia Gravis; outcome; rating scale; validation; RECOMMENDATIONS; COMPOSITE;

D O I：

10.1002/mus.24911

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Introduction: We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB-MG scale). Methods: A total of 174 patients were evaluated with the INCB-MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB-MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient. Results: Generalized and bulbar INCB-MG subscales were unidimensional with excellent consistency; the INCB-MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB-MG generalized, bulbar, and respiratory subscales. Conclusions: The INCB-MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB-MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials.

引用

页码：32 / 37

页数：6

共 15 条

[1]

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[2]

[Anonymous], 1978, Psychometric theory

[3]

Recommendations for myasthenia gravis clinical trials [J].