Design and synthesis of β-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase

被引：17

作者：

Schweitzer, BA ^{[1
]}

Loida, PJ ^{[1
]}

Thompson-Mize, RL ^{[1
]}

CaJacob, CA ^{[1
]}

Hegde, SG ^{[1
]}

机构：

[1] Monsanto Co, St Louis, MO 63167 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00338-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe the synthesis and enzymatic activity of a library of beta-carboxamido phosphonates as inhibitors of imidazole glycerol phosphate dehydratase (IGPD). Biological results suggest the presence of an enzymatic interaction Site not previously observed for other inhibitors of IGPD. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2053 / 2058

页数：6

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