A NOVEL CLASS OF HERBICIDES - SPECIFIC INHIBITORS OF IMIDAZOLEGLYCEROL PHOSPHATE DEHYDRATASE

被引：52

作者：

MORI, I

FONNEPFISTER, R

MATSUNAGA, S

TADA, S

KIMURA, Y

IWASAKI, G

MANO, J

HATANO, M

NAKANO, T

KOIZUMI, S

SCHEIDEGGER, A

HAYAKAWA, K

OHTA, D

机构：

[1] CIBA GEIGY JAPAN LTD, INT RES LABS, TAKARAZUKA, HYOGO 665, JAPAN

[2] CIBA GEIGY AG, DIV AGR, CH-4002 BASEL, SWITZERLAND

来源：

PLANT PHYSIOLOGY | 1995年 / 107卷 / 03期

关键词：

D O I：

10.1104/pp.107.3.719

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new mode of herbicidal action was established by finding specific inhibitors of imidazoleglycerol phosphate dehydratase, an enzyme of histidine (His) biosynthesis. Three triazole phosphonates inhibited the reaction of the enzyme with K-i values of 40 +/- 6.5, 10 +/- 1.6, and 8.5 +/- 1.4 nM, respectively, and were highly cytotoxic to cultured plant cells. This effect was completely reversed by the addition of His, proving that the cytotoxicity was primarily caused by the inhibition of His biosynthesis. These inhibitors showed wide-spectrum, postemergent herbicidal activity at application rates ranging from 0.05 to 2 kg/ha.

引用

页码：719 / 723

页数：5

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