Synthesis and characterization of a new thermosensitive chitosan-PEG diblock copolymer

被引：83

作者：

Ganji, F. ^{[1
]}

Abdekhodaie, M. J. ^{[1
,2
]}

机构：

[1] Sharif Univ Technol, Dept Chem Engn, Tehran, Iran

[2] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada

来源：

CARBOHYDRATE POLYMERS | 2008年 / 74卷 / 03期

关键词：

chitosan; polyethylene glycol; block copolymer; thermosensitive;

D O I：

10.1016/j.carbpol.2008.03.017

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

A novel thermosensitive hydrogel was synthesized by block copolymerization of monomethoxy poly(ethylene glycol) macromere (PEG) onto chitosan backbone, using potassium per sulfate as a free radical initiator. This block copolymer exhibits a thermoreversible transition from an injectable solution at low temperature to a gel at body temperature. Synthesized copolymers were characterized using FT-IR, H-1 NMR, C-13 NMR, and DSC techniques. Solubility test was performed to compare water and organo-solubility of chitosan before and after copolymerization. Sol-gel transition behavior was investigated using the via inversion method and viscosity measurements. The gelation behavior makes the chitosan-PEG block copolymers more promising and attractive materials for biomedical applications. (c) 2008 Elsevier Ltd. All rights reserved.

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收藏

页码：435 / 441

页数：7

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