PEG-grafted chitosan as an injectable thermoreversible hydrogel

被引：125

作者：

Bhattarai, N

Matsen, FA

Zhang, M ^{[1
]}

机构：

[1] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA

[2] Univ Washington, Dept Orthopaed & Sports Med, Seattle, WA 98195 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2005年 / 5卷 / 02期

关键词：

biocompatibility; chitosan; hydrogels; poly(ethylene glycol); viscosity;

D O I：

10.1002/mabi.200400140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PEG-grafted chitosan was formulated such that its solution undergoes a thermally reversed phase transition from an injectable free-flowing solution at low temperature to a gel at body temperature. Aqueous solutions of PEG-grafted chitosan can be prepared at physiological pH values, thereby allowing safe incorporation of bioactive molecules. This injectable thermoreversible hydrogel is potentially suitable for a wide range of biomedical applications, particularly in sustained in vivo drug release and tissue engineering.

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收藏

页码：107 / 111

页数：5

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