Novel injectable neutral solutions of chitosan form biodegradable gels in situ

被引：1225

作者：

Chenite, A

Chaput, C

Wang, D

Combes, C

Buschmann, MD

Hoemann, CD

Leroux, JC

Atkinson, BL

Binette, F

Selmani, A

机构：

[1] BIOSYNTECH Ltd, Montreal, PQ H7V 4A7, Canada

[2] Ecole Polytech, Ctr Appl Res Polymers, Dept Chem Engn, Montreal, PQ H3C 3A7, Canada

[3] Ecole Polytech, Inst Biomed Engn, Montreal, PQ H3C 3A7, Canada

[4] Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada

[5] Sulzer Biol, Wheat Ridge, CO 80033 USA

来源：

BIOMATERIALS | 2000年 / 21卷 / 21期

关键词：

chitosan; glycerophosphate; thermosetting gels; chondrocytes; bone protein;

D O I：

10.1016/S0142-9612(00)00116-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel approach to provide, thermally sensitive neutral solutions based on chitosan/polyol salt combinations is described. These formulations possess a physiological pH and can be held liquid below room temperature for encapsulating living cells and therapeutic proteins; they form monolithic gels at body temperature. When injected in vivo the liquid formulations turn into gel implants in situ, This system was used successfully to deliver biologically active growth factors in vivo as well as an encapsulating matrix for living chondrocytes for tissue engineering applications. This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2155 / 2161

页数：7

共 31 条

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