Drug Therapy for Atrial Fibrillation

被引:5
作者
Conway, Emily L. [1 ]
Musco, Simone [1 ]
Kowey, Peter R. [1 ,2 ]
机构
[1] Lankenau Hosp, Div Cardiovasc Dis, Main Line Heart Ctr, Wynnewood, PA 19096 USA
[2] Thomas Jefferson Univ, Philadelphia, PA 19107 USA
关键词
Atrial fibrillation; Pharmacologic therapy; Rhythm control; Prevention; MAINTAINING SINUS RHYTHM; ANGIOTENSIN-II ANTAGONIST; CONGESTIVE-HEART-FAILURE; N-3; FATTY-ACIDS; ANTIARRHYTHMIC-DRUGS; MYOCARDIAL-INFARCTION; RECEPTOR ANTAGONIST; SUSTAINED-RELEASE; RAPID CONVERSION; CONTROLLED-TRIAL;
D O I
10.1016/j.ccl.2008.10.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Atrial fibrillation is the most frequently diagnosed arrhythmia. Prevalence increases with age, and the overall incidence is expected to increase as the population continues to age. Choice of pharmacologic therapy for atrial fibrillation depends on whether or not the goal of treatment is maintaining sinus rhythm or tolerating atrial fibrillation with adequate control of ventricular rates. Many new antiarrhythmic drugs are currently being tested in clinical trials. Drugs that target remodeling and inflammation have shown potential in prevention of atrial fibrillation, or as adjunctive therapy.
引用
收藏
页码:109 / +
页数:16
相关论文
共 107 条
[31]   Atrial L-type Ca2+-channel, β-adrenoreceptor, and 5-hydroxytryptamine type 4 receptor mRNAs in human atrial fibrillation [J].
Grammer, JB ;
Zeng, XR ;
Bosch, RF ;
Kühlkamp, V .
BASIC RESEARCH IN CARDIOLOGY, 2001, 96 (01) :82-90
[32]  
Greenbaum RA, 1998, CIRCULATION, V98, P633
[33]   Corticosteroids for the prevention of atrial fibrillation after cardiac surgery -: A randomized controlled trial [J].
Halonen, Jari ;
Halonen, Pirjo ;
Jaervinen, Otso ;
Taskinen, Panu ;
Auvinen, Tommi ;
Tarkka, Matti ;
Hippelaeinen, Mikko ;
Juvonen, Tatu ;
Hartikainen, Juha ;
Hakala, Tapio .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (14) :1562-1567
[34]   The effect of dexamethasone on side effects after coronary revascularization procedures [J].
Halvorsen, P ;
Ræder, J ;
White, PF ;
Almdahl, SM ;
Nordstrand, K ;
Saatvedt, K ;
Veel, T .
ANESTHESIA AND ANALGESIA, 2003, 96 (06) :1578-1583
[35]   Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers - A meta-analysis [J].
Healey, JS ;
Baranchuk, A ;
Crystal, E ;
Morillo, CA ;
Garfinkle, M ;
Yusuf, S ;
Connolly, SJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (11) :1832-1839
[36]   Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter [J].
Hohnloser, SH ;
Dorian, P ;
Straub, M ;
Beckmann, K ;
Kowey, P .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 44 (01) :99-104
[37]   Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular hospitalization or death from any cause in PatiENts with atrial fibrillation/atrial flutter [J].
Hohnloser, Stefan H. ;
Connolly, Stuart J. ;
Crijns, Harry J. G. M. ;
Page, Richard L. ;
Seiz, Werner ;
Torp-Petersen, Christian .
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2008, 19 (01) :69-73
[38]  
Juhász A, 2000, PHARMAZIE, V55, P228
[39]   A 5-HYDROXYTRYPTAMINE RECEPTOR IN HUMAN ATRIUM [J].
KAUMANN, AJ ;
SANDERS, L ;
BROWN, AM ;
MURRAY, KJ ;
BROWN, MJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1990, 100 (04) :879-885
[40]   Efficacy of Azmilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart disease [J].
Kerr, Charles R. ;
Connolly, Stuart J. ;
Kowey, Peter ;
Page, Richard L. ;
Pritchett, Edward L. C. ;
Ruda, Mikhail Y. ;
Ruzyllo, Witold ;
Wilkinson, William E. .
AMERICAN JOURNAL OF CARDIOLOGY, 2006, 98 (02) :215-218