Comparative genome analysis and pathway reconstruction

被引：10

作者：

Dandekar, T

Sauerborn, R

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Inst Mol Med, D-79106 Freiburg, Germany

[3] Biozentrum, Dept Bioinformat, D-97074 Wurzburg, Germany

[4] Heidelberg Univ, Dept Trop Hyg & Publ Hlth, D-69120 Heidelberg, Germany

来源：

PHARMACOGENOMICS | 2002年 / 3卷 / 02期

关键词：

differential genome analysis; elementary modes; health system; pathway alignment; pharmacogenomics; sequence analysis;

D O I：

10.1517/14622416.3.2.245

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pathway reconstruction builds on genome and biochemical data with the aim of reconstructing higher level interactions between identified enzymes in a specific genome, in particular the different enzyme pathways (species or individual/patient). Metabolite flow in a pathway is analyzed by different tools, such as elementary mode analysis. This reveals key enzymes and pharmacological targets in the enzyme network. An overview of bioinformatic tools and algorithms for these tasks, application examples and recent results from these techniques are presented. Target selection, drug development and optimization can all be sped up using these approaches.

引用

页码：245 / 256

页数：12

共 68 条

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