Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity

被引：59

作者：

Saburi, S ^{[1
]}

McNeill, H ^{[1
]}

机构：

[1] Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X, Canada

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2005.08.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Planar cell polarity (PCP) is the coordinated organization of cells within the plane of the epithelium, first described in Drosophila. A Frizzled signalling pathway dedicated to PCP (the non-canonical Frizzled pathway) acts through Dishevelled and small G proteins, as does the classical Wnt pathway, but then diverges downstream of Dishevelled. Recent studies have demonstrated a crucial role for several atypical cadherin molecules (Fat, Dachsous and Flamingo) in controlling PCP signalling. Recent work has also indicated that the first sign of PCP during development is the polarized localization of PCP proteins (Frizzled, Flamingo, Dishevelled, etc). Exciting new data reveal that this PCP pathway is conserved to man.

引用

页码：482 / 488

页数：7

共 46 条

[1] The receptor tyrosine kinase off-track is required for layer-specific neuronal connectivity in Drosophila
Cafferty, P
Yu, L
Rao, Y
[J]. DEVELOPMENT, 2004, 131 (21): : 5287 - 5295
[2] Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
Carreira-Barbosa, F
Concha, ML
Takeuchi, M
Ueno, N
Wilson, SW
Tada, M
[J]. DEVELOPMENT, 2003, 130 (17): : 4037 - 4046
[3] Developmental compartments and planar polarity in Drosophila
Casal, J
Struhl, G
Lawrence, PA
[J]. CURRENT BIOLOGY, 2002, 12 (14) : 1189 - 1198
[4] Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
Cho, E
Irvine, KD
[J]. DEVELOPMENT, 2004, 131 (18): : 4489 - 4500
[5] Casein kinase Iε modulates the signaling specificities of dishevelled
Cong, F
Schweizer, L
Varmus, H
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (05) : 2000 - 2011
[6] PR72, a novel regulator of Wnt signaling required for naked cuticle function
Creyghton, MP
Roël, G
Eichhorn, PJA
Hijmans, EM
Maurer, I
Destrée, O
Bernards, R
[J]. GENES & DEVELOPMENT, 2005, 19 (03) : 376 - 386
[7] Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse
Curtin, JA
Quint, E
Tsipouri, V
Arkell, RM
Cattanach, B
Copp, AJ
Henderson, DJ
Spurr, N
Stanier, P
Fisher, EM
Nolan, PM
Steel, KP
Brown, SDM
Gray, IC
Murdoch, JN
[J]. CURRENT BIOLOGY, 2003, 13 (13) : 1129 - 1133
[8] The atypical cadherin flamingo links frizzled and Notch signaling in planar polarity establishment in the Drosophila eye
Das, G
Reynolds-Kenneally, J
Mlodzik, M
[J]. DEVELOPMENTAL CELL, 2002, 2 (05) : 655 - 666
[9] Planar polarity of hair cells in the chick inner ear is correlated with polarized distribution of c-Flamingo-1 protein
Davies, A
Formstone, C
Mason, I
Lewis, J
[J]. DEVELOPMENTAL DYNAMICS, 2005, 233 (03) : 998 - 1005
[10] Planar polarity from flies to vertebrates
Fanto, M
McNeill, H
[J]. JOURNAL OF CELL SCIENCE, 2004, 117 (04) : 527 - 533

← 1 2 3 4 5 →