Prediction of the dermal penetration of polycyclic aromatic hydrocarbons (PAHs): A hierarchical QSAR approach

被引:71
作者
Gute, BD [1 ]
Grunwald, GD [1 ]
Basak, SC [1 ]
机构
[1] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA
关键词
hierarchical QSAR; topological indices; geometrical indices; quantum chemical parameters; dermal penetration; polycyclic aromatic hydrocarbons;
D O I
10.1080/10629369908039162
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Attempts were made to develop hierarchical quantitative structure-activity relationship (QSAR) models for the dermal penetration of polycyclic aromatic hydrocarbons (PAHs) using four classes of theoretical structural parameters; viz., topostructural, topochemical, geometric, and quantum chemical descriptors; and physicochemical properties such as molecular weight (MW) and lipophilicity (log P - octanol/water). The results show that topostructural, topochemicaI, and geometric descriptors and molecular weight are equally effective in predicting the dermal penetration of PAHs. Quantum chemical parameters did not make any improvements in the predictive power of the QSAR models.
引用
收藏
页码:1 / 15
页数:15
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