Oxidations of erogorgiaene in pseudopterosin biosynthesis

被引：10

作者：

Ferns, T

Kerr, RG ^{[1
]}

机构：

[1] Florida Atlantic Univ, Dept Chem & Biochem, Boca Raton, FL 33431 USA

[2] Florida Atlantic Univ, Ctr Excellence Biomed & Marine Biotechnol, Boca Raton, FL 33431 USA

来源：

TETRAHEDRON | 2005年 / 61卷 / 52期

基金：

美国国家科学基金会;

关键词：

biosynthesis; diterpene; erogorgiaene; 7-hydroxyerogorgiaene; 7,8-dihydroxyerogorgiaene; pseudopterogorgia elisabethae; pseudoptersin; seco-pseudopterosin; natural product;

D O I：

10.1016/j.tet.2005.09.088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pseudopterosins are potent anti-inflammatory diterpene glycosides initially isolated from the gorgonian coral Pseudopterogorgia elisabethae. In continuation of pathway elucidation studies focused on this family of terpenes, we report the isolation of 7-hydroxyerogorgiaene and 7,8-dihydroxyerogorgiaene from P. elisabethae and confirm the intermediacy of these compounds in pseudopterosin biosynthesis by in vitro incubation experiments with these metabolites in radiolabeled form. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：12358 / 12365

页数：8

共 16 条

[1] Identification of anti-inflammatory diterpenes from the marine gorgonian Pseudopterogorgia elisabethae [J].