High-performance liquid chromatographic enantioseparations on capillary columns containing monolithic silica modified with amylose tris(3,5-dimethylphenylcarbamate)

被引：61

作者：

Chankvetadze, B

Yamamoto, C

Kamigaito, M

Tanaka, N

Nakanishi, K

Okamoto, Y ^{[1
]}

机构：

[1] Nagoya Univ, EcoTopia Sci Inst, Chikusa Ku, Nagoya, Aichi 4648603, Japan

[2] Kyoto Univ, PRESTO, JST, Grad Sch Engn,Dept Mat Chem,Sakyo Ku, Kyoto 6068501, Japan

[3] Kyoto Univ, Dept Polymer Sci & Engn, Sakyo Ku, Kyoto 6068501, Japan

[4] Nagoya Univ, Grad Sch Engn, Dept Appl Chem, Chikusa Ku, Nagoya, Aichi 4648603, Japan

[5] Tbilisi State Univ, Sch Chem, Mol Recognit & Separat Sci Lab, GE-028 Tbilisi, Georgia

来源：

JOURNAL OF CHROMATOGRAPHY A | 2006年 / 1110卷 / 1-2期

关键词：

capillary liquid chromatography; monolithic capillary columns; amylose tris(3,5-dimethylphenylcarbamate); chiral stationary phase; enantioseparations;

D O I：

10.1016/j.chroma.2006.01.076

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Monolithic capillary columns containing native silica were modified by in situ coating with amylose tris(3,5-dimethylphenylcarbamate) and applied for enantioseparations in capillary liquid chromatography. Capillary columns were examined for 10 standard racemic compounds in order to compare the performance of monolithic silica columns with the common, 4.6 mm I.D. high-performance liquid chromatographic columns packed with particulate silica. The effects of polysaccharide coating and of the linear velocity of the mobile phase on peak performance were studied. Enantioseparations with an analysis time below 1 min were achieved for some chiral analytes. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：46 / 52

页数：7

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