Heterocyclic nucleoside analogues: Design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles

被引：105

作者：

Lee, YS ^{[1
]}

Kim, BH ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Natl Res Lab, Ctr Integrated Mol Syst,Div Mol & Life Sci, Pohang 790784, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(02)00182-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have designed and synthesized novel antiviral nucleoside analogues, which consist of isoxazole rings as modified sugars and nucleobases (thymine, uracil, and 5-fluorouracil) with a methylene linker between them. These compounds represent a new class of modified nucleoside analogues and some of them show potent antiviral activities against Polio virus (Coxsackie B type 3 and Vesicular Stomatitis). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1395 / 1397

页数：3

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