Ruthenium(II)-assisted asymmetric hydrogen transfer reduction of acetophenone using chiral tridentate phosphorus-containing ligands derived from (1R, 2R)-1,2-diaminocyclohexane

被引：18

作者：

Flores-López, CZ ^{[1
]}

Flores-López, LZ ^{[1
]}

Aguirre, G ^{[1
]}

Hellberg, LH ^{[1
]}

Parra-Hake, M ^{[1
]}

Somanathan, R ^{[1
]}

机构：

[1] Inst Tecnol Tijuana, Ctr Grad & Invest, Tijuana 22000, BC, Mexico

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2004年 / 215卷 / 1-2期

关键词：

asymmetric; Ruthenium(II); transfer; hydrogenation; Schiff base;

D O I：

10.1016/j.molcata.2004.01.013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Several chiral and unsymmetrical tridentate [NNP]-type ligands with sp(2)-N and sp(3)-N were synthesized from monosulfonamide of (1R, 2R)-1,2-diaminocyclohexane and 2-(diphenylphosphino)benzaldehyde. Their ruthenium(II) complexes have been used in the enantioselective asymmetric hydrogen transfer reduction of acetophenone in 2-propanol with selectivities in the range 14-99% e.e. The good enantioselectivity with the ligands with sp(2)-N and sp(3)-N is believed to be due to formation of hexacoordinated complexes with a 2:1 ligand to metal ratio. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：73 / 79

页数：7

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