Protein structure modeling for structural genomics

被引：155

作者：

Sánchez, R ^{[1
]}

Pieper, U ^{[1
]}

Melo, F ^{[1
]}

Eswar, N ^{[1
]}

Martí-Renom, MA ^{[1
]}

Madhusudhan, MS ^{[1
]}

Mirkovic, N ^{[1
]}

Sali, A ^{[1
]}

机构：

[1] Rockefeller Univ, Pels Family Ctr Biochem & Struct Biol, Labs Mol Biophys, New York, NY 10021 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2000年 / 7卷 / Suppl 11期

关键词：

D O I：

10.1038/80776

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The shapes of most protein sequences will be modeled based on their similarity to experimentally determined protein structures. The current role, limitations, challenges and prospects for protein structure modeling (using information about genes and genomes) are discussed in the context of structural genomics.

引用

页码：986 / 990

页数：5

共 35 条

[11] Pathways to a protein folding intermediate observed in a 1-microsecond simulation in aqueous solution [J].

Duan, Y ;

Kollman, PA .

SCIENCE, 1998, 282 (5389) :740-744

[12] Assigning folds to the proteins encoded by the genome of Mycoplasma genitalium [J].

Fischer, D ;

Eisenberg, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :11929-11934

[13]

Fischer D, 1999, PROTEINS, P209

[14] Protein modelling for all [J].

Guex, N ;

Diemand, A ;

Peitsch, MC .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (09) :364-367

[15] Homology-based fold predictions for Mycoplasma genitalium proteins [J].

Huynen, M ;

Doerks, T ;

Eisenhaber, F ;

Orengo, C ;

Sunyaev, S ;

Yuan, YP ;

Bork, P .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 280 (03) :323-326

[16] GenTHREADER: An efficient and reliable protein fold recognition method for genomic sequences [J].

Jones, DT .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 287 (04) :797-815

[17] Protein structure prediction in the postgenomic era [J].

Jones, DT .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (03) :371-379

[18] A brighter future for protein structure prediction [J].

Patrice Koehl ;

Michael Levitt .

Nature Structural Biology, 1999, 6 (2) :108-111

[19]

Koonin Eugene V., 2000, Trends in Genetics, V16, P16, DOI 10.1016/S0168-9525(99)01927-7

[20] DREAM++: Flexible docking program for virtual combinatorial libraries [J].

Makino, S ;

Ewing, TJA ;

Kuntz, ID .

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1999, 13 (05) :513-532

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