Differential working memory load effects after mild traumatic brain injury

被引:349
作者
McAllister, TW
Sparling, MB
Flashman, LA
Guerin, SJ
Mamourian, AC
Saykin, AJ
机构
[1] Dartmouth Coll, Hitchcock Med Ctr, Sect Neuropsychiat, Lebanon, NH 03756 USA
[2] Dartmouth Coll, Hitchcock Med Ctr, Brian Imaging Lab, Lebanon, NH 03756 USA
[3] Dartmouth Coll, Hitchcock Med Ctr, Dept Psychiat, Lebanon, NH 03756 USA
[4] Dartmouth Coll, Hitchcock Med Ctr, Dept Radiol, Lebanon, NH 03756 USA
关键词
D O I
10.1006/nimg.2001.0899
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The objective of this study was to explore the effects of increasing working memory (WM) processing load on previously observed abnormalities in activation of WM circuitry shortly after mild traumatic brain injury (AMI). Brain activation patterns in response to increasing WM processing load (auditory n-back: 0-, 1-, 2-, and 3-back conditions) were assessed with fMRI in 18 MTBI patients within 1 month of their injury and in 12 healthy controls. Performance accuracy on these tasks was also measured. Brain activation patterns differed between MTBI patients and controls in response to increasing WM processing loads. Controls maintained their ability to increase activation in regions of WM circuitry with each increase in WM processing load. MTBI patients showed disproportionately increased activation during the moderate processing load condition, but very little increase in activation associated with the highest processing load condition. Task performance did not differ significantly between groups on any task condition. MTBI patients showed a different pattern of allocation of processing resources associated with a high processing load condition compared to healthy controls, despite similar task performance. This suggests that injury-related changes in ability to activate or modulate WM processing resources might underlie some of the memory complaints after MTBI. (C) 2001 Academic Press.
引用
收藏
页码:1004 / 1012
页数:9
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