Guarding the frontiers: the biology of type III interferons

被引：285

作者：

Wack, Andreas ^{[1
]}

Terczynska-Dyla, Ewa ^{[2
]}

Hartmann, Rune ^{[2
]}

机构：

[1] Francis Crick Inst, Mill Hill Lab, London, England

[2] Aarhus Univ, Dept Mol Biol & Genet, Aarhus, Denmark

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 08期

基金：

英国医学研究理事会;

关键词：

IFN-LAMBDA RECEPTOR; CHRONIC HEPATITIS-C; ANTIVIRAL ACTIVITY; GENETIC-VARIATION; DIFFERENTIAL EXPRESSION; VIRUS-REPLICATION; STIMULATED GENES; EPITHELIAL-CELLS; I INTERFERONS; HCV CLEARANCE;

D O I：

10.1038/ni.3212

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type III interferons (IFNs) or IFN-lambda s regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-lambda s primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier tissues. IFN-lambda s thereby help to maintain healthy mucosal surfaces through immune protection, without the significant immune-related pathogenic risk associated with type I IFN responses. Type III IFNs also target the human liver, with dual effects: they induce an antiviral state in hepatocytes, but specific IFN-lambda 4 action impairs the clearance of hepatitis C virus and could influence inflammatory responses. This constitutes a paradox that has yet to be resolved.

引用

收藏

页码：802 / 809

页数：8

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