Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

被引：375

作者：

Garraway, Levi A. ^{[1
,2
,5
,6
]}

Jaenne, Pasi A. ^{[1
,3
,4
,5
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

[2] Dana Farber Canc Inst, Ctr Canc Genome Discovery, Boston, MA 02215 USA

[3] Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USA

[4] Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA 02215 USA

[5] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[6] Broad Inst Harvard & MIT, Cambridge, MA USA

来源：

CANCER DISCOVERY | 2012年 / 2卷 / 03期

关键词：

GROWTH-FACTOR-RECEPTOR; CHRONIC MYELOID-LEUKEMIA; TYROSINE KINASE INHIBITORS; CELL LUNG-CANCER; ACQUIRED-RESISTANCE; BCR-ABL; MULTIDRUG-RESISTANCE; MET AMPLIFICATION; BREAST-CANCER; GEFITINIB RESISTANCE;

D O I：

10.1158/2159-8290.CD-12-0012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

All successful cancer therapies are limited by the development of drug resistance. The increase in the understanding of the molecular and biochemical bases of drug efficacy has also facilitated studies elucidating the mechanism(s) of drug resistance. Experimental approaches that can help predict the eventual clinical drug resistance, coupled with the evolution of systematic genomic and proteomic technologies, are rapidly identifying novel resistance mechanisms. In this review, we provide a historical background on drug resistance and a framework for understanding the common ways by which cancers develop resistance to targeted therapies. We further discuss advantages and disadvantages of experimental strategies that can be used to identify drug resistance mechanism(s). Significance: Increased knowledge of drug resistance mechanisms will aid in the development of effective therapies for patients with cancer. We provide a summary of current knowledge on drug resistance mechanisms and experimental strategies to identify and study additional drug resistance pathways. Cancer Discovery; 2(3); 214-26. (c) 2012 AACR.

引用

页码：214 / 226

页数：13

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