Update and rationale for ongoing acute myocardial infarction trials: Combination therapy, facilitation, and myocardial preservation

被引:7
作者
Herrmann, Howard C. [1 ]
机构
[1] Hosp Univ Penn, Cardiac Catheterizat Lab, Philadelphia, PA 19104 USA
关键词
D O I
10.1016/j.ahj.2006.04.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Advancements in the treatment of myocardial infarction such as coronary care units, patient education, improved emergency response systems, and reperfusion therapy have reduced mortality. However, in an effort to further reduce the present rate by improving potency rates and microcirculatory perfusion, by better preserving myocardium, and/or treating shock more effectively, more research is,under way to improve strategies now in place and to develop new, more effective ways to treat these patients.
引用
收藏
页码:S30 / S39
页数:10
相关论文
共 61 条
[31]   Mortality at 1 year with combination platelet glycoprotein IIb/IIIa inhibition and reduced-dose fibrinolytic therapy vs conventional fibrinolytic therapy for acute myocardial infarction - GUSTO V randomized trial [J].
Lincoff, AM ;
Califf, RM ;
Van de Werf, F ;
Willerson, JT ;
White, HD ;
Armstrong, PW ;
Guetta, V ;
Gibler, WB ;
Hochman, JS ;
Bode, C ;
Vahanian, A ;
Steg, PG ;
Ardissino, D ;
Savonitto, S ;
Bar, F ;
Sadowski, Z ;
Betriu, A ;
Booth, JE ;
Wolski, K ;
Waller, M ;
Topol, EJ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (17) :2130-2135
[32]   Gene therapy for myocardial angiogenesis -: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia [J].
Losordo, DW ;
Vale, PR ;
Symes, JF ;
Dunnington, CH ;
Esakof, DD ;
Maysky, M ;
Ashare, AB ;
Lathi, K ;
Isner, JM .
CIRCULATION, 1998, 98 (25) :2800-2804
[33]  
MEHTA SR, 2005, ESC C 2005 SEPT 3 7
[34]   Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction. [J].
Montalescot, G ;
Barragan, P ;
Wittenberg, O ;
Ecollan, P ;
Elhadad, S ;
Villain, P ;
Boulenc, JM ;
Morice, MC ;
Maillard, L ;
Pansiéri, M ;
Choussat, R ;
Pinton, P .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (25) :1895-1903
[35]   Evaluation of the time saved by prehospital initiation of reteplase for ST-elevation myocardial infarction - Results of the Early Retavase-Thrombolysis In Myocardial Infarction (ER-TIMI) 19 trial [J].
Morrow, DA ;
Antman, EM ;
Sayah, A ;
Schuhwerk, KC ;
Giugliano, RP ;
deLemos, JA ;
Waller, M ;
Cohen, SA ;
Rosenberg, DG ;
Cutler, SS ;
McCabe, CH ;
Walls, RM ;
Braunwald, E .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (01) :71-77
[36]   Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States - National Registry of Myocardial Infarction (NRMI)-3/4 analysis [J].
Nallamothu, BK ;
Bates, ER ;
Herrin, J ;
Wang, YF ;
Bradley, EH ;
Krumholz, HM .
CIRCULATION, 2005, 111 (06) :761-767
[37]   Effect of glycoprotein IIb/IIIa receptor blockade with abciximab on clinical and angiographic restenosis rate after the placement of coronary stents following acute myocardial infarction [J].
Neumann, FJ ;
Kastrati, A ;
Schmitt, C ;
Blasini, R ;
Hadamitzky, M ;
Mehilli, J ;
Gawaz, M ;
Schleef, M ;
Seyfarth, M ;
Dirschinger, J ;
Schömig, A .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (04) :915-921
[38]   Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction [J].
Neumann, FJ ;
Blasini, R ;
Schmitt, C ;
Alt, E ;
Dirschinger, J ;
Gawaz, M ;
Kastrati, A ;
Schömig, A .
CIRCULATION, 1998, 98 (24) :2695-2701
[39]   A PROSPECTIVE, PLACEBO-CONTROLLED, RANDOMIZED TRIAL OF INTRAVENOUS STREPTOKINASE AND ANGIOPLASTY VERSUS LONE ANGIOPLASTY THERAPY OF ACUTE MYOCARDIAL-INFARCTION [J].
ONEILL, WW ;
WEINTRAUB, R ;
GRINES, CL ;
MEANY, TB ;
BRODIE, BR ;
FRIEDMAN, HZ ;
RAMOS, RG ;
GANGADHARAN, V ;
LEVIN, RN ;
CHOKSI, N ;
WESTVEER, DC ;
STRZELECKI, M ;
TIMMIS, GC .
CIRCULATION, 1992, 86 (06) :1710-1717
[40]  
ONEILL WW, 2003, TCT 2003 15 ANN TRAN