Correlation of the structure, properties, and antimicrobial activity of a soluble thiolated chitosan derivative

被引：22

作者：

Han, Bing ^{[2
,3
]}

Wei, Yan ^{[3
,4
]}

Jia, Xiaolong ^{[1
]}

Xu, Juan ^{[1
]}

Li, Gang ^{[1
]}

机构：

[1] Beijing Inst Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China

[2] Peking Univ Sch, Dept Orthodont, Beijing 100081, Peoples R China

[3] Hosp Stomatol, Beijing 100081, Peoples R China

[4] Peking Univ Sch, Dept Geriatr Dent, Beijing 100081, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2012年 / 125卷

关键词：

biological applications of polymers; biomaterials; biopolymers; DEACETYLATION; CONJUGATE; DELIVERY; CHITIN; FILMS;

D O I：

10.1002/app.36548

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

A thiolated chitosan (CS) derivative was synthesized by the introduction of thioglycolic acid to CS via amide-bond formation mediated by carbodiimide. The chemical structure of the CS derivative was confirmed by Fourier transform infrared spectroscopy and 1H-NMR spectroscopy. The solubility test showed that the thiolated CS derivative was water-soluble. The X-ray pattern of the CS derivative showed an obvious disappearance or shift of crystalline peaks compared to that of CS. Thermogravimetric analysis indicated that the degradation peak temperature of the thiolated CS derivative was much higher than that of CS and implied an improved thermal stability at higher temperatures. Moreover, the antimicrobial activity of the thiolated CS derivative was comparable to that of CS. (C) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

引用

页码：E143 / E148

页数：6

共 36 条

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Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications [J].