Physical activity, waist-to-hip ratio, and other risk factors for ovarian cancer: A follow up study of older women

被引：100

作者：

Mink, PJ ^{[1
]}

Folsom, AR ^{[1
]}

Sellers, TA ^{[1
]}

Kushi, LH ^{[1
]}

机构：

[1] UNIV MINNESOTA,SCH PUBL HLTH,DIV EPIDEMIOL,MINNEAPOLIS,MN 55454

来源：

EPIDEMIOLOGY | 1996年 / 7卷 / 01期

关键词：

ovarian neoplasms; cohort studies; exercise; obesity;

D O I：

10.1097/00001648-199601000-00008

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We investigated the association of epithelial ovarian cancer with physical activity, waist-to-hip ratio, reproductive factors, and family history of cancer in a prospective cohort study of 31,396 postmenopausal women. Ninety-seven women developed incident epithelial ovarian cancer over 7 years. The number of livebirths was associated with lower risk (multivariate-adjusted relative risks for 1-2, 3-4, and >4 livebirths compared with nulliparity were 0.64, 0.47, and 0.43, respectively). A family history of ovarian cancer in a first degree relative was associated with a 2.5 times greater risk (95% confidence interval = 0.90-6.7). Multivariate-adjusted relative risks for the upper three quartiles of waist-to-hip ratio compared with the lowest quartile were 2.0, 1.6, and 2.3, respectively. Women with ''moderate'' and ''high'' levels of physical activity compared with those with ''low'' physical activity had relative risks of 1.4 and 2.1, respectively. Positive associations of physical activity and waist to-hip ratio with ovarian cancer seem inconsistent with existing theories of ovarian cancer pathogenesis.

引用

页码：38 / 45

页数：8

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