Preparation and characterization of inclusion complexes of pefloxacin mesylate with three kinds of cyclodextrins

被引：18

作者：

Chao, JB ^{[1
]}

Tong, HB ^{[1
]}

Liu, DS ^{[1
]}

Huang, SP ^{[1
]}

机构：

[1] Shanxi Univ, Inst Modern Chem, Taiyuan 030006, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2006年 / 64卷 / 01期

关键词：

NMR; inclusion capacity; fluorescence;

D O I：

10.1016/j.saa.2005.07.012

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The ability of alpha-cyclodextrin, beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin (alpha-CD, beta-CD and HP-beta-CD) to break pefloxacin mesylate (PM) aggregates by forming inclusion complexes has been studied using H-1 NMR (nuclear magnetic resonance spectroscopy), C-13 NMR and fluorescence spectra. The inclusion constants are determined to compare the corresponding inclusion capacity. Solid-inclusion complexes of PM with CDs are synthesized by coprecipitation method, and all the inclusion ratios are found to be 1:1. Additionally, spatial characterization of complexes has been proposed based on two-dimensional nuclear magnetic resonance technique (2D NMR) and spatial conformation is also investigated to propose two possible models between PM and CDs. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：166 / 170

页数：5

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